Tizanidine for myofascial pain and sciatica. "The research suggests tizanidine can be used with other pain treatments to relieve the symptoms in people with sciatica." Dr Tisch told news.com.au he was looking for a painkiller sufferers of spinal stenosis, a condition that can cause painful pressure inside the spine, but would prefer to start at lower doses, since the results from previous studies have been variable. But in a letter published online the European Spinal Cord Journal, an independent scientific journal funded jointly by the National Health and Medical Research Council the Victorian Department of Human Services, he acknowledged the potential benefit, adding it would be a "long journey" towards clinical use. "In the near future, tizanidine could be used for the treatment of patients with spinal stenosis both ends," he and his co-authors, from the University of Oxford, and UQ School Medicine, said. "However, as tizanidine is a strong analgesic and the use of opioids has increased following the availability of high-dose cocaine, I believe it is time for an evaluation of alternative agents for pain relief in people who are taking opioids," he added. The researchers said in people using the drug as an analgesic, doses were typically "minimal or only a milligram" per day. "There is no good evidence at present which suggests that higher tizanidine-based doses would be beneficial for people in recovery," Dr Poulton and colleagues from the University of Oxford said, adding they were "in search of more suitable opioid agonists" to experiment with. In a second letter, published last week in the online edition of Clinical Pain, Dr Poulton and his co-authors said it would be a "long-term research topic" to explore other benefits, such as pain relief for people with diabetes or chronic pain conditions such as rheumatoid arthritis. But "given the existing evidence which suggests that tizanidine's efficacy in this setting is modest, a clinical trial of such drug in people with pain may be impractical," they concluded. The Buy generic valium 10mg University of Oxford team will be reviewing the findings in more detail next week, said Professor David Goadsby, a neuropharmacologist and one of the paper's co-authors. Dr. Poulton will be returning to the USA in a fortnight, Professor Goadsby told news.com.au. "Given the number of patients coming to Oxford with serious symptoms of pain, we'd be concerned they wouldn't get the benefit of a good quality medical study," he said. "But if it did give an overall benefit in people with mild symptoms, that's a worthy outcome of that research and in the process probably finding people that wouldn't otherwise be available to us if the pain was very serious." If a positive outcome was shown, it could pave the way for more research into the therapeutic use of this anti-inflammatory, Prof. Goadsby said. "It could give a boost to lot of people in their pain, but the only way it would be available to them is if it was well-controlled and a lot better." Meanwhile, in the United States, a similar trial of lower dose was trialled in a small group of patients in 2008. In the UK, it was recommended that the painkiller not be used beyond five days, because it "is not without potential risks". Doctors did not need a prescription, and could prescribe it at any time they considered it medically appropriate.
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